What is Immunotherapy for Prostate Cancer

Immunotherapy is a beneficial treatment for men with prostate cancer, particularly those with incurable advanced-stage or recurrent form of the disease. The treatment works by activating your immune system to attack the cancer cells, shrinking the tumor or causing it to disappear altogether. Used alone or in combination with other treatments, like chemotherapy, hormone therapy or radiation therapy, immunotherapy is able to reverse the growth of prostate cancer after the other treatment options have failed.

How does it work?

Like many other tumors, prostate cancer evades the immune system by deactivation of T-cells, the blood cells that attack foreign materials and abnormal cells in the body. So immunotherapeutic approaches are designed in a way to enhance the response of the immune system to cancer cells by reactivation of the T-cells.

During immunotherapy, immature immune cells are obtained from a man with prostate cancer. This is done to allow the cells to get out of the environment where they can be detected and deactivated by the cancer cells as soon as they are mature. The immature cells then are re-engineered by combining them with an artificial version of PAP, the antigen expressed by 95 percent of prostate cancer cells. After re-engineering, they are supplied with a factor (GM-CSF) that boosts their survival, growth and maturity once they are infused back into the body.

Meticulously re-engineered, activated, trained and matured T-cells are infused back into the body — now with the ability to attack and destroy cancer cells. They act as antibodies against the cancer cells and are able to detect and eliminate the cancer cells. The infusion of re-engineered cells or antibodies against prostate cancer is done three times. But as the treatment goes on, you still will be on the treatment or drugs you were already taking prior to immunotherapy. That will allow your body to produce enough activated, trained and matured T-cells to fight the prostate cancer without ever again being deactivated or bypassed by the cancer.

Why should you consider immunotherapy for prostate cancer?

Immunotherapy is an amazing and highly effective treatment for the cancer. During treatment, your cancer treatment team can use a wide variety of immune-based strategies to develop antibodies against the tumor, killing the cancer cells and preventing its recurrence. It offers excellent results in men with advanced-stage hormone resistant prostate cancer and reduces the risk of cancer recurrence in men with high-risk, localized tumors when it is administered in combination with hormone therapy. The treatment increases the survival rate from prostate cancer and enhances life expectancy by several years.

At Advanced Urology Institute, we are offering immunotherapy as a treatment option for prostate cancer, particularly tumors that have spread beyond the prostate or become resistant. And as our understanding of how cancer cells relate with the immune system deepens, we are tapping into that knowledge to help improve treatment outcomes for our patients. So if you have been diagnosed with prostate cancer, find out from your urologist if immunotherapy may be of help in your situation. Want to know more about the treatment options for prostate cancer? Visit the “Advanced Urology Institute” site.

Cryotherapy An Alternative Treatment to Radiation Therapy for Prostate Cancer

Cryotherapy means using extremely cold temperatures to freeze and destroy cancer cells. Also called cryoablation or cryosurgery — though not actually a form of surgery — cryotherapy relies on the principle that cancer cells are typically more sensitive to freezing than normal cells. So when an area affected by cancer is exposed to the very low temperatures, cancer cells die while normal cells survive the treatment. While cryotherapy can be used to treat earlier-stage prostate cancer, it isn’t used as the first treatment. It is also a great option for treating prostate tumor that’s resistant or recurs after radiation therapy. However, like brachytherapy, this treatment is not ideal for men with enlarged prostate glands.

How is it performed?

During cryotherapy, the doctor uses a trans-rectal ultrasound (TRUS) to direct several hollow needles (probes) through an incision made on the skin between the scrotum and anus and into the prostate. A very cold (freezing) fluid, such as argon gas or nitrogen liquid, is infused into the prostate via the probes (needles) and used to freeze and kill cancerous prostate cells. To prevent damage to healthy, nearby tissues, the doctor uses the ultrasound to carefully monitor the process and target the tumor with more precision.

Also, to prevent urethral damage, a warm saline solution is circulated via a catheter in the urethra to stop it from freezing. The catheter may be left in place for many weeks afterward to enable the bladder to empty during recovery. Cryotherapy requires epidural (spinal) or general anesthesia. After the procedure, patients may remain in the hospital overnight, although many usually leave on the same day.

How cryotherapy works

Living cells — normal or abnormal — cannot endure extreme cold. That’s why when the prostate gland is infused with liquid nitrogen or argon gas it quickly loses heat, the ice balls or ice crystals swell instantaneously, and the cell membranes rupture, followed by tissue damage and then cell death. After cancer is destroyed, the dead cells and tissues are cleaned up from the body by white blood cells. Also, the body’s immune system is triggered to strike out, attack and destroy any remaining cancer cells.

Cryotherapy provides several advantages over radiation and surgery, particularly in early-stage prostate cancer. It’s a less invasive procedure that can be performed using spinal or epidural anesthesia instead of general anesthesia. This is especially important when treating prostate cancer in older men. It is also beneficial for men with prostate cancer occurring simultaneously with conditions such as lung disease, heart disease or diabetes. Cryotherapy causes less blood loss, pain and swelling, requires shorter hospital stay (1-2 nights) and involves a shorter recovery period. Also, when necessary, cryotherapy can be followed by surgery or radiation therapy.

Effective alternative to radiation therapy

Even with early intervention and prompt radiotherapy, about 30-40 percent of men still experience a return of prostate cancer. Hence, further treatment is almost always necessary after radiation therapy. Cryotherapy is a great option for preventing cancer recurrence or treating recurrent prostate cancer in cases where the initial radiation therapy fails to kill enough cells. The need to use cryotherapy is determined by conducting follow-up PSA tests after radiotherapy. High PSA levels after radiotherapy implies either radio-resistance or incomplete eradication of cancer cells and cryoprobes can then be used to prevent a recurrence, particularly when the tumor is still localized. When used this way, cryotherapy is very effective — freezing the area and killing cancer cells while sparing normal cells. For more information on safe, effective treatment of prostate cancer, visit the “Advanced Urology Institute” site.