Testosterone Therapy May Lower Prostate Cancer Incidence

Testosterone replacement therapy (TRT) may help to reduce the risk of prostate cancer. According to a case-control study authored by Stacy Loeb, MD, MSc, of New York University, men who undergo testosterone replacement therapy (TRT) have lower risk of prostate cancer than those who do not undergo the therapy. Plus, the study found that testosterone therapy decreases the risk of aggressive prostate cancer, which is the form of the cancer that usually requires treatment.

Linking testosterone level to prostate cancer

The New York University study was based on the National Prostate Cancer Register of Sweden and included all the 38, 570 cases of prostate cancer diagnosed in Sweden from 2009 to 2012, together with 192,838 age-matched men without prostate cancer.

During the research, 284 prostate cancer patients (1%) and 1378 healthy men (1%) completed prescription forms for TRT. Then following a multivariable analysis, it was established that exposure to TRT did not produce increased prostate cancer risk.

On the contrary, TRT exposure resulted in reduced risk of the cancer within the first year and decreased the risk of the aggressive type of the disease after the first year of therapy.

Need for more studies

While the above study by New York University into the link between TRT and risk of prostate cancer was not conclusive, it demonstrated a reduced risk of the cancer after testosterone therapy. Besides, due to the increased administration of TRT in recent years, this study generated more issues that need further studies.

For instance, due to the more favorable-risk of prostate cancer in men who receive the therapy, the study pointed to the need for increased prostate cancer screening in men undergoing TRT. Also, it pointed to several possible biologic mechanisms involved in aggressive disease, including the role of testosterone in normal functioning of the prostate and epithelial cell differentiation.

Efficacy of testosterone therapy in several studies

Another study presented at the Sexual Medicine Society of North America 18th Annual Fall Scientific Meeting in San Antonio, Texas reported that hypogonadal men who receive TRT have reduced incidence of prostate cancer than those not receiving the therapy. The study also found that the form of prostate cancer diagnosed in recipients of testosterone therapy is less severe than the form diagnosed in men unexposed to the therapy.

The study was conducted in 400 hypogonadal men (those with testosterone level of 350 ng/dL or less) and who received testosterone undecanoate 1000 mg every 3 months for up to 10 years. It also involved a control group of 376 hypogonadal men who were not receiving TRT. A median follow-up of 8 years was done, where 9 men in the TRT group (2.3%) were diagnosed with prostate cancer compared to 26 men (6.9%) in the control group.

The diagnosed men in the TRT group underwent radical prostatectomy (RP). All of them except one patient had a Gleason score of 6 or less. In fact, most had a predominant Gleason score of 3 and all had tumor grade G2 and tumor stage T2.
On the contrary, in the control group, 18 required radical prostatectomy alone, 6 required both RP and radiation, while 2 required radiation. Plus, 26 patients in the control group had a Gleason score above 6, 2 had a score of 3, 20 had a score of 4, and 4 had a score of 5. The tumor grade was G2 in 6 patients and G3 in 20 patients; while in terms of tumor stage, 1 patient had stage T2 with 25 were at stage T3.

In the testosterone group, all the cancer cases were diagnosed within the first year. This suggested that the tumors had been present before the therapy was initiated. Since low testosterone is linked with low PSA, the cancer was probably not detected before testosterone therapy due to hypogonadism. The detection within one year of treatment was due to increasing levels of testosterone, which brought out occult cancer.

There are several other studies that have produced similar reports. For example, a population-based matched cohort study of men aged 66 years or older by the University of Toronto demonstrated that testosterone exposure reduces the risk of prostate cancer by up to 40-percent.

The research in Ontario, Canada by Christopher J.D. Wallis, MD, PhD, and colleagues was published in the Lancet Diabetes Endocrinology (2016;4:498-506) and involved exposure of the men to the highest tertile testosterone and comparing the results with controls. During the study 10,311 men received TRT while 28,029 men did not. Follow-up was made after 5.3 years in the TRT group and after 5.1 years in the control group.

Prompt prostate cancer diagnosis and treatment

Are you a man over the age of 50 years and would like to begin prostate cancer screening? Or are you having urinary issues and suspect you could be developing a prostate-related disorder?

At Advanced Urology Institute, we have assembled a skilled, experienced team of board-certified urologists to help diagnose and treat prostatic issues, including prostatitis, enlarged prostate and prostate cancer.

Our state-of-the art prostate cancer center is supplied with the latest equipment and technology to deliver prompt diagnosis and safe, effective treatment of prostatic problems. For more information on prostate cancer and other urologic disorders, visit the site AdvancedUrologyInstitute.com

Benefits of Testosterone Therapy

Secreted primarily in the testicles, testosterone is a critical hormone responsible for male growth and masculine characteristics. The levels of testosterone increase exponentially in childhood and hit a peak during adolescence, then begin to decline by about 1 percent every year between the ages of 30 and 40 years and older. The gradual decline can be due to either normal aging processes or a condition called hypogonadism. Hypogonadism is a disorder in which the body fails to produce normal quantities of testosterone. It often occurs when there is a problem with the pituitary gland (which controls the testicles) or with the testicles themselves. For men with testosterone levels below the normal range, testosterone replacement therapy can relieve symptoms of low-T and provide many benefits.

Normal Testosterone Levels

For men, the normal range of total testosterone is 300-1,200 ng/dL (nanograms per deciliter). Men with testosterone levels within this range rarely have any problems associated with low testosterone. However, since total testosterone does not usually provide the full picture, doctors often measure and use the levels of free testosterone to assess a man’s vulnerability to low-T symptoms. Free testosterone means the amount of testosterone hormone that is active in the body at any given time. Men with total testosterone levels within the normal range can still suffer from the classic low-T symptoms if their free testosterone levels fall short.

Implications of Low Free Testosterone

The free testosterone level is a clearer indicator of a man’s true testosterone status. In fact, low free-T is almost exclusively associated with sex difficulties. Low testosterone diminishes sex drive in men and results in loss of energy and motivation and poor performance in bed. Men with low testosterone also may suffer from fewer spontaneous erections, slightly lower sperm count, increased body fat, decreased muscle strength and mass, fragile bones, tenderness or swelling of breast tissue, hot flashes, increased fatigue, feelings of depression and sadness, trouble with concentration and memory, lowered self-confidence and motivation, and a degraded overall sense of well-being. These symptoms can be relieved through testosterone replacement therapy.

Benefits of Testosterone Replacement Therapy

There is no doubt that testosterone replacement therapy (TRT) can quickly revive a man’s interest in sex, boost his ability to maintain an erection and recreate the “wow” factor of his orgasms. Treating sexual symptoms is a good enough reason for men to start testosterone therapy. But because testosterone therapy also can improve a man’s health beyond the bedroom, bringing testosterone levels back to normal is a good decision for every man who wants to feel better. Replacement therapy improves bone mineral density, boosts overall bone strength, increases muscle mass and strength, boosts red blood cell production, enhances hemoglobin levels and corrects both iron deficiency anemia and unexplained anemia. Testosterone therapy also improves mood, alleviates depression, irritability and fatigue, relieves disorders linked to testosterone deficiency such as osteoporosis and boosts insulin sensitivity, which can benefit men with diabetes or minimize the risk of diabetes in men with functioning pancreas.

Should You Opt For Testosterone Therapy?

Testosterone replacement therapy is ideal for men with testosterone levels below 300 ng/dL or those experiencing symptoms of low testosterone. Undergoing replacement therapy can help you restore your testosterone levels to normal and improve your libido, cognition, mood, bone density, muscle mass and red blood cell production. However, you should remember that the therapy is only necessary if you have low T. If you are not sure whether the therapy is right for you, speak with your doctor. The doctor will conduct the requisite tests for low-T and guide you accordingly.

At Advanced Urology Institute, we help men recover from their old, tired and depressed selves through safe and effective testosterone replacement therapy. We deliver this therapy after accurate measurements of testosterone levels to ensure that we give testosterone only to the right people. If you have symptoms of low-T or suspect that your levels could be low, speak to one of our urologists. We will ensure to get you back to a more energetic, motivated and happy self. For more information on the diagnosis and treatment for low testosterone, visit the “Advanced Urology Institute” site.

Prostate Cancer, A Common and Treatable Cancer in Men – Dr Matthew Merrell

Video: Prostate Cancer, A Common and Treatable Cancer in Men – Dr Matthew Merrell

Prostate cancer is the most common cancer among men (excluding skin cancers). It accounts for 43 percent of all male cancers. Despite these startling facts, prostate cancer does not have to be life threatening. Contact a urologist now and get treatment for this condition as soon as possible. [Read Full Article…]

Low Testosterone Screening, How Can I Find out if I Have Low T – Jeanette Lain, PA C

Video: Low Testosterone Screening, How Can I Find out if I Have Low T – Jeanette Lain, PA C

Testosterone is a steroid hormone belonging in the androgen group (males) that is primarily secreted in the testicles. Testosterone is considered to be the primary sex hormone for the male species. Contact a professional now and get treatment for this condition as soon as possible. [Read Full Article…]

Becoming a Physician Assistant, Why did You Choose Urology – Jeanette Lain, PA C

Video: Becoming a Physician Assistant, Why did You Choose Urology – Jeanette Lain, PA C

Ms. Jeanette Lain has extensive urology experience, previously serving as a Physician Assistant for Urology Centers of Oklahoma with the Women’s Bladder Clinic, Unitus Clinic for Sexual Health and general urology care. [Read Full Article…]

Being a Urologist, A Very Gratifying Medical Career – Dr Matthew Merrell

Video: Being a Urologist, A Very Gratifying Medical Career – Dr Matthew Merrell

Dr. Merrell is certified by the American Board of Urology and is a fellow of the American College of Surgeons. He is a member of the American Medical Association, the American Urological Association, the Florida Urologic Association and the Volusia County Medical Society. [Read Full Article…]

Is Testosterone Therapy Right for You? Dr. Karavadia Explains How to Diagnose Low Levels


  • Testosterone is a crucial hormone for men, affecting their daily energy levels, sexuality, and overall health.
  • Low testosterone can cause various symptoms, including fatigue, hot flashes, gynecomastia, and low libido.
  • Treatment options for low testosterone include patches, gels, injections, and long-term pellet therapy.


Testosterone is a vital hormone for men, impacting their daily energy levels, sexuality, and overall health. Dr. Saumil Karavadia, a renowned urologist in Ocala, FL, provides insight into the symptoms of low testosterone, the importance of proper evaluation, and the available treatment options. Read on to learn more about testosterone therapy and how it could potentially benefit you.

The Importance of Testosterone for Men’s Health

According to Dr. Saumil Karavadia, MD, testosterone is a key hormone needed for men to maintain their health. Low testosterone levels can lead to numerous issues such as osteoporosis, decreased energy levels, and fatigue. Some individuals may experience symptoms similar to male menopause, including hot flashes, gynecomastia (enlarged breast tissue), low libido, and persistent fatigue.

Diagnosing Low Testosterone: Seeking Evaluation

If you suspect you may have low testosterone, Dr. Karavadia recommends seeking a professional evaluation to determine the cause. In many cases, low testosterone levels result from primary testicular failure, where the testicles do not produce enough of the hormone. This condition often requires testosterone therapy for treatment.

Testosterone Therapy Options

There are several treatment options available for low testosterone, including patches, gels, injections, and long-term pellet options. Dr. Karavadia highlights the convenience of pellet therapy, as it allows patients to receive treatment every three to four months, reducing the need for frequent visits to the clinic.

The Benefits of Testosterone Therapy

Patients who undergo testosterone therapy often experience a significant increase in their energy levels, allowing them to be more active and enjoy their daily lives. Additionally, testosterone therapy can improve libido, overall well-being, and alleviate feelings of fatigue or depression that can occur with age.

Advanced Urology Institute: Expertise You Can Trust

Dr. Saumil Karavadia is a dedicated urologist at the Advanced Urology Institute, the largest urology practice in Florida. Their commitment to providing exceptional care ensures that patients receive the best possible treatment for low testosterone and other urological concerns. Trust the experts at Advanced Urology Institute to guide you on your journey to improved health and well-being.


My name is Saumil Karavadia, I’m with Advanced Urology Specialists.

Testosterone is a male hormone that certainly has a big impact on a male’s sexuality as well as the daily energy that a person goes through from a day-to-day basis. Testosterone is one of the key hormones that’s needed to actually be healthy.

If you have low testosterone, it can certainly lead to osteoporosis, worsening energy levels, being tired. The majority of the symptoms are having like a male menopause. Hot flashes, gynecomastia, low libido, low fatigue. Those are all very common symptoms of having low testosterone. 

First thing is you’ll want to get evaluated. You’ll want to get checked out for the most common causes for this. And majority of the time it’s primary testicular failure where the testicles itself, they don’t produce any testosterone. When that happens, you need to supplement with testosterone therapy. And that’s one of the most common ways to treat it. There are several treatment options including patches, gels, injections, as well as long-term pellet options which are great for people who want to come in every three or four months and just get one treatment.

Once you start testosterone therapy, the patients have a significant increase in their energy. They’re sleeping not throughout the day. They’re being active and enjoying their lifestyle. They also have an increase in libido. They have an increase in their well-being. They don’t have that tired or fatigued feeling which is a big cause for being depressed almost as you get older.


Why Shouldn’t You Feel Embarrassed About Erectile Dysfunction? Insights from Dr. Dinesh Rao


  • Increased awareness and open conversations about erectile dysfunction can help break the stigma surrounding the condition, encouraging more people to seek help.
  • The widespread recognition of ED and the availability of treatment options have made it easier for individuals to discuss their concerns with a healthcare professional.
  • The Advanced Urology Institute, the largest urology practice in Florida, offers comprehensive care for patients experiencing erectile dysfunction, including treatment from leading urologist Dr. Dinesh S. Rao.

Introduction: Breaking the Stigma

Erectile dysfunction (ED) is a common condition that affects many men, yet the topic has long been considered taboo or embarrassing to discuss. Dr. Dinesh S. Rao, a leading urologist in Ocala, FL, believes that increased awareness and open conversations about ED can help break the stigma, encouraging more people to seek help and receive the treatment they need.

The Role of Publicity and Awareness

According to Dr. Rao, the increased publicity surrounding ED medications has been beneficial for patients. The widespread awareness of the condition and the availability of treatment options have made it easier for people to talk about their experiences with ED. As a result, more individuals feel comfortable discussing their concerns with a healthcare professional and seeking appropriate help.

Normalizing the Conversation Around Erectile Dysfunction

The term “erectile dysfunction” has become more widely recognized and understood, which has helped normalize conversations around the condition. Dr. Rao emphasizes that this increased awareness is crucial, as it allows both men and women to recognize that ED is a widespread problem and not a source of embarrassment. By fostering open discussions about ED, more people are likely to seek help and receive the appropriate treatment.

Seeking Help at the Advanced Urology Institute

The Advanced Urology Institute, the largest urology practice in Florida, is committed to providing comprehensive care for patients experiencing erectile dysfunction. With a team of skilled professionals, including Dr. Dinesh S. Rao, the Advanced Urology Institute offers innovative treatment options and a supportive environment for patients dealing with ED.


I think the greater amount of publicity that the medications have evoked are actually very good for patients. I think many people were very nervous or shy to ask about erectile dysfunction. Even the phrase erectile dysfunction has become something that most people have now heard of, whereas before they didn’t even have that phrase. And so I think it’s actually been very helpful. People are now not quite as afraid to mention it when they come in for an office visit. I think the awareness is important because then women and men both can realize that this is a widespread problem and it’s not an embarrassment to ask for help with it. The more that people ask for help, the more they’ll receive it. So I think the awareness of erectile dysfunction, the awareness that it is very prevalent in that aging population is a good thing and I don’t really see any negatives about it.


Low Testosterone Therapy Risks and Benefits

A decrease in testosterone production is thought to be a normal part of the aging process and usually begins after the age of 30. This change occurs gradually, but can have a significant effect on a person’s overall health. Contact a urologist now and get treatment for this condition as soon as possible. Other causes of testosterone insufficiency include: [Read Full Article…]